. 2007 Mar 29;581(Pt 3):1271–1282. doi: 10.1113/jphysiol.2007.129197

Table 1.

Effects of two doses of amiloride injected into the popliteal artery on the cardioaccelerator responses to lactic acid, static contraction, capsaicin and tendon stretch

	Large dose (5.0 μg kg⁻¹)		Small dose (0.5 μg kg⁻¹)

	Change	Baseline HR	Change	Baseline HR
Lactic acid
Before	5 ± 2^*	217 ± 6	7 ± 3^**	196 ± 6
30 min	2 ± 1^†	228 ± 6	1 ± 1^†	210 ± 7
60 min	2 ± 1^†	242 ± 8	7 ± 2^**	240 ± 7
Static contraction
Before	9 ± 3^***	213 ± 7	17 ± 4^***	183 ± 6
30 min	4 ± 2^**^†	222 ± 7	7 ± 2^†	201 ± 6
60 min	2 ± 1^†	243 ± 7	15 ± 2^***	224 ± 9
Capsaicin
Before	16 ± 4^*	208 ± 6	13 ± 2^***	193 ± 7
30 min	10 ± 3^*	220 ± 7	14 ± 3^***	205 ± 7
60 min	3 ± 1^†	234 ± 9	15 ± 3^***	240 ± 10
Tendon stretch
Before	8 ± 3^**	212 ± 6	7 ± 2^**	188 ± 6
30 min	3 ± 1^†	228 ± 6	8 ± 2^*	200 ± 6
60 min	0 ± 0^†	242 ± 7	9 ± 3^**	228 ± 7

Asterisks denote significance from baseline value (

P < 0.05;

^**

P < 0.01;

^***

P < 0.001). Daggers denote significance from value before amiloride injection (

^†

P < 0.05).