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. 2007 Mar 22;581(Pt 3):961–970. doi: 10.1113/jphysiol.2006.121822

Figure 5.

Figure 5

LTD of the parabrachial input requires activation of NMDA receptors and a rise in postsynaptic calcium A, averaged normalized responses from 8 neurons that were loaded with 10 mm BAPTA. At time 0, low-frequency (1 Hz) stimulation was delivered for 900 stimuli. LTD induction is blocked by postsynaptic BAPTA. B and C, slices were incubated in either the NMDA receptor antagonist d-AP5 (30 μm, B, n = 13) or the selective NR2B antagonist CP101606 (5 μm, C, n = 12). Low-frequency stimulation was delivered at time 0. LTD induction was blocked when postsynaptic NMDA receptors were antagonized.