Table 2.
Modelled parameters and the changes producing greatest error reduction
| Parameter | Description | Standard model | Data for uninvolved limb | Data for involved limb | Data for age-matched controls |
|---|---|---|---|---|---|
| ENR | Resting membrane potential | −82.9 | −82.9 | NC | −82.9 |
| PNaN | Permeability of Na+ channels at the node | 4.1 | 4.1 | 4 | 4.4 |
| PNaP% | % of Na+ channels that are persistent | 0.895 | 1.12 | 1.16 | 1.12 |
| GKsN | Max. conductance of slow K+ channels at the node | 41 | 49 | 51 | 45.5 |
| GKsI | Max. conductance of slow K+ channels at the internode | 0.365 | 0.145 | 0.145 | 0.145 |
| GKfN | Max. conductance of fast K+ channels at the node | 20 | 20 | 22.5 | 24 |
| GKfI | Max. conductance of fast K+ channels at the internode | 100 | 106 | 106 | 106 |
| GH | Max. conductance of IH | 6.3 | 7.6 | 5.3 | 6.55 |
| GLkN | Leak conductance at the node | 1.38 | 0.865 | 0.9 | 0.865 |
| GLkI | Leak conductance at the internode | 1.6 | 1.28 | 0.29 | 1.25 |
| Tabs | Temperature (K) | 301.8 | 303.7 | 303.8 | 304 |
NC, not clamped. The standard model was first adjusted to produce an optimal fit for the data for the uninvolved limb, and then the further changes necessary to produce an optimal fit for the data for the involved limb were made. Relevant key changes are in bold and italics.