Table 1.
Analysis of the amino acids of V1aR +/+ and V1aR −/− mice under the fasting and feeding conditions
| Feeding versus fasting | ||||||||
|---|---|---|---|---|---|---|---|---|
| Feeding condition | Fasting condition | P value | P value | |||||
| Amino acids | V1aR +/+ | V1aR −/− | P value | V1aR +/+ | V1aR −/− | P value | (V1aR +/+) | (V1aR −/−) |
| Aspartic acid | 14.0 ± 0.8 | 14.9 ± 0.7 | 0.418 | 8.3 ± 0.3 | 6.7 ± 0.2 | 0.008** | 0.0002*** | 0.0001*** |
| Threonine | 174.5 ± 6.8 | 127.5 ± 9.4 | 0.004** | 155.2 ± 7.6 | 125.4 ± 6.8 | 0.02* | 0.0962 | 0.8661 |
| Serine | 157.4 ± 8.3 | 121.5 ± 8.2 | 0.015* | 104.4 ± 5.1 | 108.5 ± 5.9 | 0.618 | 0.0006*** | 0.2375 |
| Asparagine | 50.6 ± 4.2 | 36.0 ± 2.2 | 0.015* | 49.5 ± 1.8 | 47.6 ± 4.3 | 0.699 | 0.8094 | 0.0452* |
| Glutamic acid | 62.7 ± 5.1 | 52.5 ± 3.7 | 0.145 | 43.3 ± 1.7 | 36.6 ± 2.3 | 0.055 | 0.0069** | 0.0069** |
| Glutamine | 576.6 ± 26.5 | 630.4 ± 28.9 | 0.207 | 529.5 ± 16.5 | 562.5 ± 33.5 | 0.403 | 0.1703 | 0.1644 |
| Proline | 111.4 ± 16.6 | 77.4 ± 8.8 | 0.108 | 69.9 ± 1.1 | 74.3 ± 3.46 | 0.267 | 0.0376* | 0.7511 |
| Glycine | 365.5 ± 20.5 | 259.2 ± 6.1 | 0.001*** | 198.8 ± 3.4 | 227.6 ± 6.24 | 0.004** | 0.0001*** | 0.0067** |
| Alanine | 440.3 ± 39.7 | 410.5 ± 49.8 | 0.652 | 279.1 ± 15.3 | 258.5 ± 14.9 | 0.363 | 0.0053** | 0.0191* |
| Citrulline | 58.6 ± 5.8 | 60.6 ± 4.3 | 0.787 | 42.0 ± 2.2 | 49.0 ± 3.1 | 0.108 | 0.0296* | 0.0605 |
| Valine | 216.1 ± 19.0 | 163.8 ± 9.4 | 0.039* | 239.8 ± 9.2 | 191.2 ± 14.1 | 0.021* | 0.2935 | 0.1455 |
| Cysteine | 4.3 ± 1.4 | 3.4 ± 0.9 | 0.607 | ND | ND | |||
| Methionine | 63.2 ± 5.5 | 42.1 ± 4.0 | 0.014* | 52.0 ± 1.59 | 44.7 ± 2.4 | 0.037* | 0.0871 | 0.5844 |
| Isoleucine | 88.5 ± 8.3 | 67.5 ± 4.4 | 0.057 | 114.3 ± 2.4 | 93.6 ± 7.7 | 0.034* | 0.0175* | 0.0187* |
| Leucine | 148.4 ± 17.5 | 116.0 ± 8.5 | 0.134 | 202.7 ± 7.0 | 163.1 ± 11.8 | 0.021* | 0.0204* | 0.012* |
| Tyrosine | 69.2 ± 4.6 | 49.8 ± 3.4 | 0.01** | 54.1 ± 0.7 | 56.68 ± 5.0 | 0.632 | 0.0124* | 0.2876 |
| Phenylalanine | 66.0 ± 5.8 | 57.4 ± 4.0 | 0.255 | 75.0 ± 1.9 | 72.76 ± 1.6 | 0.401 | 0.1764 | 0.0072** |
| Ornithine | 92.8 ± 11.6 | 55.3 ± 4.2 | 0.016* | 53.3 ± 0.7 | 64.7 ± 4.2 | 0.023* | 0.0095** | 0.1409 |
| Lysine | 324.0 ± 17.3 | 247.3 ± 16.0 | 0.012* | 236.1 ± 7.0 | 223.1 ± 6.9 | 0.226 | 0.0015** | 0.2038 |
| Arginine | 145.5 ± 9.5 | 132.0 ± 10.3 | 0.366 | 119.6 ± 6.2 | 101.5 ± 5.2 | 0.056 | 0.0528 | 0.0293* |
| Tryptophan | 56.1 ± 3.4 | 46.9 ± 3.3 | 0.086 | 38.3 ± 2.0 | 44.1 ± 2.0 | 0.086 | 0.0022** | 0.4975 |
| Histidine | 59.2 ± 2.7 | 60.8 ± 4.3 | 0.763 | 55.9 ± 2.3 | 58.2 ± 2.5 | 0.504 | 0.3768 | 0.6217 |
| Total amount | 3344 ± 138.2 | 2832 ± 113.7 | 0.021* | 2724 ± 61.2 | 2612 ± 83.2 | 0.309 | 0.0034** | 0.1569 |
| Urea | 9131.0 ± 762.2 | 8369.0 ± 500.7 | 0.428 | 11 109.1 ± 625.9 | 11 207.8 ± 1087.7 | 0.939 | 0.0798 | 0.0451* |
Values are the means ± s.e.m. (nmol ml−1). These results were obtained from five mice. ND, not detectable. Asterisks show significance(
***
P < 0.001
**
P < 0.01 and
*
P < 0.05).