Table 1.
Parameters used in the simulations
| k012 (m−1 s−1) | k021 (s−1) | k25 (s−1) | k52 (m−1 s−1) | k15 (s−1) | k51 (s−1) | k23 (m−1 s−1) | k32 (s−1) | k035 (s−1) | k53 (m−2 s−1) | k24 (m−1 s−1) | k42 (s−1) | k045 (s−1) | k54 (m−2 s−1) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KAAT1 Na+ | 126 | 359 | 2 | 70.2 | 20 | 2000 | 1 × 106 | 0.2 | 4 | 7.02 × 105 | 3 × 105 | 50 | 500 | 1.1 × 105 |
| KAAT1 K+ | 126 | 359 | 2 | 70.2 | 20 | 2000 | 1 × 106 | 0.2 | 3000 | 3.51 × 108 | 300 | 300 | 200 | 7020 |
Rates denoted with the ‘0’ superscript represent the zero voltage value. The constants k52, k53 and k54 were calculated to ensure micro reversibility (Läuger, 1991). The values of α, β and δ were, respectively, set at 0.5, 0.3, 0.2 for Na+ and 0.3, 0.6, 0.1 for K+. The external and internal concentrations of the organic substrates were set at 500 μm and 10 μm, respectively. For Na+ they were 100 mm and 7 mm, while for K+ they were both 100 mm.