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. 2007 Mar 29;581(Pt 3):1221–1233. doi: 10.1113/jphysiol.2007.129262

Table 2.

Change in Isc in anti-CD3-injected mice

Sham-injected Anti-CD3 mAb-injected


G (mS cm−2) Basal Isc cAMP-stimulated Isc G (mS cm−2) Basal Isc cAMP-stimulated Isc
Basal 11.5 ± 1.1 0.6 ± 2.1 3.0 ± 0.16 13.3 ± 1.4 2.1 ± 0.14 2.5 ± 0.18
NPPB  12.6 ± 1.1ns 0.3 ± 0.9* 0.3 ± 0.04*  13.5 ± 1.1ns 0.4 ± 0.05* 0.4 ± 0.05*
Glibenclamide  12.1 ± 1.2ns  0.4 ± 1.9**  0.3 ± 0.06**  14.1 ± 1.1ns  0.3 ± 0.05** 0.24 ± 0.06**

Experiments were done in the presence of luminal Cl and HCO3-containing Ringer solution. Isc (μEq h−1 cm2) after addition of 10 μm forskolin are taken from the highest values. Values represent mean ± s.e.m.n = 12 in the basal group and n = 6 in which blockers were added.

*

P < 0.001, comparison between presence and absence (basal) of NPPB.

**

P < 0.001, comparison between presence and absence (basal) of glibenclamide. ns = no significant difference between the groups.