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Representative tension traces (left) and mean values (right) showing the effects of AICAR (0.1, 1, 3 mM) on isolated AMPKα1+/+ (A) and AMPKα1−/− (B) mouse aortic rings after phenylephrine-induced contraction, in the absence or in the presence of SPT (10 μM) plus DPSX (30 nM), L-NMMA (30 μM), or after removal of the endothelium Results are expressed as means ± s.e.m. of 4–6 mice aorta. *P < 0.05, **P < 0.01 versus control conditions.
