Figure 6.

The effect of change in β₂ subunit ratio on the expression of α₆β₂δ and α₁β₂γ₂ receptors A, the current traces of receptor–channels from the expression of 1α₆ : 0.1 β₂ : 1.8δ, 1α₆ : 0.3 β₂ : 1.8δ, or control 1α₆ : 1 β₂ : 1.8δ ratios. The dotted line indicates the zero-current level; the shaded area represents the spontaneous activity. The thick lines above the current traces represent the duration of GABA application. B, the GABA concentration–response relationship for the three tested ratios of α₆, β₂, and δ subunits. The data derived from 1α₆ : 0.1 β₂ : 1.8δ and 1α₆ : 0.3 β₂ : 1.8δ were fitted with a single Hill equation, while the data for 1α₆ : 1 β₂ : 1.8δ were fitted with a sum of two Hill equations. C, the concentration–response relationship for 1α₁ : 0.08 β₂ : 1.8γ_2S, 1α₁ : 0.4 β₂ : 1.8γ_2S and control1α₁ : 1 β₂ : 1.8γ_2S subunit combination.