Table 3.
Spontaneous, GABA-induced (20–50× their relative EC50 values) and pentobarbital-evoked (1 mm) maximum currents (nA) for different GABAA receptor subtypes
| GABAAR subtype | Spontaneous | GABA | Pentobarbital | ImaxPB/ImaxGABA | n |
|---|---|---|---|---|---|
| α6β2δ | 98 ± 13.2 | 318 ± 14 | 1027 ± 53 | 326 ± 15% | 30 |
| α6β2γ2S | 50 ± 5.9 | 1499 ± 98 | 2156 ± 122 | 147 ± 4% | 25 |
| α4β2δ | 38 ± 4 | 1440 ± 110 | 1185 ± 127 | 83 ± 2% | 24 |
| α1β2γ2S | 31 ± 3.6 | 1874 ± 138 | 1974 ± 210 | 106 ± 6% | 25 |
| α1β2δ | 26 ± 2.9 | 1136 ± 173 | 570 ± 144 | 39 ± 6% | 27 |
| Control | Leak | ||||
| Mock-injected | 23 ± 2.5 | — | — | — | 16 |