Table 1.
Demographic and Clinical Characteristics of TLE Patients with and without Major Depressive Disorder (MDD)
| Characteristic | TLE Patients with MDD (N = 16) | TLE Patients without MDD (N = 21) | |
|---|---|---|---|
| N (%) | N (%) | Fisher’s Exact p | |
| Current Major Depressive Episode | 5 (31) | NA | NA |
| Sex (Female) | 9 (56) | 6 (29) | .11 |
| Anxiety Disorder (Any) | 5 (31) | 2 (10) | .20 |
| Generalized Anxiety Disorder | 2 (13) | 1 (5) | .57 |
| Panic Disorder | 1 (6) | 0 (0) | .43 |
| Social Phobia | 3 (19) | 1 (5) | .30 |
| Obsessive Compulsive Disorder | 1 (6) | 0 (0) | .43 |
| Alcohol Abuse | 2 (13) | 1 (5) | .57 |
| Cannabis Abuse | 2 (13) | 0 (0) | .18 |
| Focus | .74 | ||
| Right | 6 (38) | 10 (48) | |
| Left | 8 (50) | 10 (48) | |
| Bilateral | 1 (6) | 0 (0) | |
| Unknown | 1 (6) | 1 (5) | |
| Mesial Temporal Sclerosis | 8 (50) | 10 (48) | 1.00 |
| Other focal neuropathology | 1 (6) | 2 (10) | 1.00 |
| Family history (FH) | |||
| FH epilepsy | 5 (31) | 6 (29) | 1.00 |
| FH major depressive disorder | 4 (25) | 4 (19) | .71 |
| FH alcohol dependence | 7 (44) | 4 (19) | .15 |
| Mean (SD) | Mean (SD) | t, p | |
| Age (Years) | 38.5 (12.0) Range: 20-55 | 35.4 (11.8) Range: 18-55 | 0.78, .44 |
| Age at onset of seizures (Years) | 15.0 (11.1) | 16.0 (10.0) | 0.29, .78 |
| Epilepsy Duration (Years) | 23.5 (16.9) | 19.4 (11.9) | 0.86, .40 |
| Age at onset of MDD (Years) | 20.8 (8.4) | NA | NA |
| Major Depressive Episodes | 2.4 (1.6) | NA | NA |
| Beck Depression Inventory | 14.4 (13.0)a | 5.3 (5.2)b | 2.72, .01 |
a
2 scores missing
b
3 scores missing