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. 2008 Jan 2;118(1):6–14. doi: 10.1172/JCI32483

Figure 1. Simplified schematic of a DA synapse showing synthesis of DA, a postsynaptic D2 receptor, and intracellular mechanisms.

Figure 1

Most conventional and atypical antipsychotics block DA D2 receptors. The D2 receptor is coupled by an inhibitory G protein (Gi) to adenylyl cyclase (AC), which converts ATP to cAMP, a secondary messenger.