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. 2005 Oct 24;171(2):209–215. doi: 10.1083/jcb.200505018

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — Zyxin is required for actin stress fiber reinforcement in response to mechanical stimulation. (A) F-actin (phalloidin) in zyxin +/+ and −/− fibroblasts before (−) or after (+) cyclic stretch. Note the thinner stress fibers in stretched zyxin −/− cells. (B) SFTI was measured over a 1-h time course of stretch stimulation. Zyxin-null (−/−) fibroblasts showed an impaired actin thickening response (*, P < 0.05). (C) Phalloidin staining and SFTI analysis indicated that the expression of GFP-zyxin in zyxin −/− cells rescued the stress fiber reinforcement response (*, P < 0.05 vs. +/+; ^†, P < 0.05 vs. −/−). (D) Comparison of the alignment index of zyxin +/+ and −/− cells over an 8-h time course of stretch stimulation. Error bars represent SEM.