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. 2005 Dec 5;171(5):857–869. doi: 10.1083/jcb.200507061

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Copyright © 2005, The Rockefeller University Press

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Figure 2. — Depletion of endogenous Ral by RNAi decreases branching. Cortical neurons fixed and stained for RalA, RalB, and tubulin 50 h after nucleofection of the indicated siRNA duplexes. (A) Neurons nucleofected with control siRNA display branched neurites visualized by the tubulin staining. RNAi of RalA (B), RalB (C), and both Ral isoforms (D) decreases branching complexity, particularly in major neurites. Bar, 50 μm. (E) Quantitative analysis of branching from major neurites of cortical neurons after RNAi for RalA, RalB, or both Ral isoforms (means ± SEM: control RNAi, 3.39 ± 0.19; RalA RNAi, 1.41 ± 0.11; RalB RNAi, 0.91 ± 0.13; RalA + RalB RNAi, 0.77 ± 0.09; **, P < 0.0001).