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. 2005 Dec 5;171(5):799–810. doi: 10.1083/jcb.200506083

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Copyright © 2005, The Rockefeller University Press

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Figure 7. — Model depicting how the nesprins can link the nucleus to the actin and IF cytoskeletal systems. Nesprin-3 at the ONM and the integrin β4 subunit at the cell surface are shown bound to the NH₂-terminal plectin ABD. COOH-terminal plectin plakin repeats are free to make associations with IFs, thus linking the nucleus to the hemidesmosomes at the cell surface. In an analogous way, nesprin-1/2 and talin, bound to the cytoplasmic tail of β integrins, interact with the actin filaments, which link the nucleus to FCs (black, IF cytoskeleton; green, MT system; red, F-actin). MTOC, MT organizing center.