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. 2005 Dec 19;171(6):1073–1084. doi: 10.1083/jcb.200503155

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — Paxillin association with α₄ integrins stabilizes adhesive tethers to immobilized α₄-specific mAbs independent of ligand-induced rearrangements. (A) Dose-dependent induction of the 15/7 epitope by the α₄β₁-specific ligand Bio1211 on wt α₄ or α₄(Y991A)–expressing Jurkat cells. (B) Reduced tethering and firm adhesion of the α₄(Y991A) mutant to immobilized α₄ mAb (HP1/2) under shear flow. Frequency of tethers and their categories were determined as in Fig. 7. (C) Strength of adhesion developed by JB4 expressing either wt or α₄(Y991A) settled for 1 min on low or high density mAb. Experiments in A and B are each representative of three independent experiments. Error bars represent SD.