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. 2005 Aug 29;170(5):781–791. doi: 10.1083/jcb.200502148

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Figure 1. — Characterization of emerin null fibroblasts. (a) Western analysis of homozygous (−/− and −/Y) and heterozygous (+/−) emerin null and wild-type (+/+ and +/Y) adult muscle fibroblasts, showing a complete lack of emerin in the homozygous cells. Protein expression of lamin A/C and lamin B1 appeared normal in the emerin null homozygous and heterozygous cells. (b) Female heterozygous (i.e., Emd ^+/−) muscle fibroblasts stained with anti-emerin antibody (left) and DAPI (right). Two cells (*) clearly lack emerin staining (as visualized by comparing with the DAPI staining), reflecting the differential X-chromosome inactivation in the heterozygous cell population.