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. 2005 Aug 29;170(5):781–791. doi: 10.1083/jcb.200502148

Figure 5.

Figure 5.

Emerin and A-type lamin-deficient cells are more sensitive to mechanical strain. (a) A-type lamin-deficient cells have a significantly increased number of propidium iodide–positive cells after 24 h of cyclic, 10% biaxial strain application. Emerin-deficient cells are not significantly different from wild-type cells. (Percentage of propidium iodide–positive cells at rest vs. after 24 h strain application = 0.13 ± 0.03% vs. 0.38 ± 0.12%, 0.2 ± 0.00% vs. 0.37 ± 0.04%, and 0.68 ± 0.18% vs. 2.94 ± 0.47% for wild-type, emerin-deficient, and A-type lamin-deficient cells respectively, P < 0.01 for wild-type vs. A-type lamin-deficient strained cells; P < 0.05 for wild-type vs. A-type lamin-deficient controls). (b) Emerin and A-type lamin-deficient cells have increased fractions of apoptotic cells after 24 h of cyclic, 10% biaxial strain application (percentage of apoptotic cells at rest vs. after 24 h of strain application = 0.37 ± 0.05% vs. 0.30 ± 0.04% for wild-type, 0.43 ± 0.02% vs. 0.70 ± 0.06% for emerin-deficient, and 0.72 ± 0.05% vs. 1.04 ± 0.11% for A-type lamin-deficient cells; P < 0.001 for strained emerin and A-type lamin-deficient vs. wild-type cells).