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. 2005 Jul 4;170(1):21–26. doi: 10.1083/jcb.200502153

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — NOD2 membrane association is COOH-terminal dependent. (A) Sequences of Flag-NOD2 COOH-terminal deletion and substitution mutants. (B) Caco-2 cells were transfected with Flag-NOD2 mutant constructs. Mutants 1–12 were detected by confocal microscopy using monoclonal anti-Flag antibody followed by fluorescein-conjugated anti–mouse IgG. Membrane association is still observed for some NOD2 mutants (arrows). (C) COS7 cells were transfected with GFP-NOD2 3020insC and were stained with calnexin (ER marker). Some of the observed vesicles colocalized with calnexin (arrows). Bars, 20 μm.