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. 2005 Jul 18;170(2):295–304. doi: 10.1083/jcb.200409117

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — A model for antagonism between Akt (survival) and JNK (apoptotic) signals via 14-3-3 proteins. (a) Exposure of a cell to survival signals results in inhibiting apoptosis by the 14-3-3–mediated sequestration of Akt-phosphorylated proapoptotic proteins such as Bad and FOXO3a. (b) Reduced survival signals promote dephosphorylation of proapoptotic proteins, resulting in the release of these proteins from 14-3-3 and, thus, leading to cell death. (c) Potent (sustained) apoptotic signals promote JNK-mediated phosphorylation of 14-3-3, resulting in the release of proapoptotic proteins from 14-3-3 and cell death. P shown in pink and blue circles represents Akt- and JNK-mediated phosphorylation, respectively.