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. 2005 Jul 18;170(2):273–283. doi: 10.1083/jcb.200502055

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Figure 6. — The exocyst and Sro7/77p mediate the signaling from Rho3p and Sec4p to the SNAREs. The GTP-bound form of Sec4p controls the exocyst through its direct interaction with Sec15p (Guo et al., 1999b), whereas the GTP-bound form of Rho3p controls the exocyst through its interaction with Exo70p (Adamo et al., 1999; Robinson et al., 1999). Exo84p directly interacts with Sro7/77p. Genetic analyses suggest that the exocyst complex mediates the signaling from Rho3p and Sec4p to Sro7/77p, which regulate SNARE assembly. Sro7p and Sro77p play an important regulatory role in the communication between the exocyst and t-SNAREs. The genetic analyses do not totally exclude the possibility that Sec4p and Rho3p regulate Sro7p in parallel to the exocyst. Besides interacting with the secretory machinery, Sro7p and Sro77p may also interact with cytoskeleton and polarity regulators. Other members of the exocyst complex are not shown in the diagram.