Figure 4.

Cd36 ^−/− macrophages demonstrate impaired early responses to whole S. aureus and, to a lesser extent, E. coli. Wild-type and Cd36 ^−/− macrophages were treated with 10:1 S. aureus (a) or E. coli (b) for 4 h, and TNFα, IL-12, and IL-6 were measured in cell culture supernatants. *, P ≤ 0.05; **, P ≤ 0.005, significantly different from wild-type macrophages.