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. 2005 Aug 15;170(4):537–549. doi: 10.1083/jcb.200502154

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — DNA demethylation increases the dynamics of both SUV39H1 and SUV39H1-ΔSET but not that of HP1β. NIH3T3 cells were transfected with EYFP-SUV39H1, EYFP–SUV39H1-ΔSET, or with EYFP-HP1β and were treated with 5 μM 5-aza-C. After 48–52 h of treatment, a heterochromatic area was selected and photobleached. Images were recorded just before and at different time intervals after photobleaching. The corresponding FRAP curves are plotted together with the FRAP curves for EYFP-SUV39H1, EYFP–SUV39H1-ΔSET, and EYFP-HP1β obtained from nontreated cells. Curves represent the means from 18, 12, and 16 cells, respectively, and show that both EYFP-SUV39H1 and EYFP–SUV39H1-ΔSET become more dynamic after 5-aza-C treatment.