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. 2005 Sep 26;170(7):1101–1111. doi: 10.1083/jcb.200504035

Figure 3.

Figure 3.

Lithium accelerates clearance of mutant huntingtin fragment by inositol monophosphatase inhibition. The percentage of EGFP-HDQ74–positive cells with aggregates and cell death in COS-7 (A) and SK-N-SH (B) cells as in Fig. 1, A and B, treated with or without 10 μM SB216763 or 100 μM L-690,330 for 48 h, were expressed as odds ratios. (C) Clearance of soluble EGFP-HDQ74 in stable inducible PC12 cell lines as in Fig. 1 C, treated with (+) or without (−) 100 μM L-690,330 for 170 h, was analyzed by immunoblotting with antibody against EGFP (i) and densitometry (ii). (D) Clearance of A53T (i) and A30P (ii) α-synucleins in stable inducible PC12 cells as in Fig. 2, A and B, treated with (+) or without (−) 100 μM L-690,330 for 24 h, was analyzed by immunoblotting with antibody against HA. (E) Clearance of soluble EGFP-HDQ74 in stable inducible PC12 cell lines as in Fig. 1 C, treated with (+) or without (−) 10 μM SB216763 for 170 h, was analyzed by immunoblotting with antibody against EGFP (i) and densitometry (ii). (F) Clearance of A53T (i) and A30P (ii) α-synucleins in stable inducible PC12 cells as in Fig. 2, A and B, treated with (+) or without (−) 10 μM SB216763 for 24 h, was analyzed by immunoblotting with antibody against HA. ***, P < 0.001; NS, non-significant.