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. 2005 Sep 26;170(7):1127–1134. doi: 10.1083/jcb.200503011

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — CASK expression is reduced in MALS-deficient mice. (A) Brains from E18 mice were immunoblotted for numerous synaptic proteins. (B) CASK was markedly reduced (31% of control ± 8; *, P < 0.01) in the TKOs, but no changes in other synaptic proteins were detected. (C and D) Similarly, cultured hippocampal neurons lacking MALS displayed normal localization of several pre- and postsynaptic markers but showed reduced colocalization of CASK (red) and synaptophysin (green), suggesting that CASK is partially lost from synapses (62% ± 12 of control; *, P < 0.01). Bars: (top) 10 μm; (bottom) 5 μm. All error bars represent SEM.