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. 2005 Jan 17;168(2):315–328. doi: 10.1083/jcb.200408177

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — Model for nucleotide's role in Arp2/3 complex function. (A) Proposed relative contributions of Arp2 and Arp3 nucleotide binding to actin filament nucleation and a yet to be determined structural activity. (B) Proposed steps in an endocytic pathway (Merrifield et al., 2002; Kaksonen et al., 2003) affected by Arp2 and Arp3 nucleotide-binding mutants. Both Arp2 and Arp3 mutants affect the initiation and the rate of actin assembly at endocytic sites (i), but Arp3 mutants more dramatically inhibit internalization of endocytic proteins as a consequence of defects in actin network structure and integrity (ii).