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. 2005 Jun 6;169(5):813–824. doi: 10.1083/jcb.200412008

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — β2-Syntrophin, but not the β1 isoform, interacted with and clustered ARMS, and the PH1 domain was required for syntrophin-induced ARMS clustering. (A and B) Immunoprecipitation of ARMS and HA–β-syntrophins from cotransfected COS7 cell homogenates. HA–β2-syntrophin (B), but not HA–β1-syntrophin (A), was coimmunoprecipitated with ARMS 892 antiserum. (C) Immunostaining of ARMS and HA–β-syntrophin–overexpressing cells. Only HA–β2-syntrophin, but not HA–β1-syntrophin, elicited ARMS clustering. Bar, 10 μm. (D) PH1-deleted HA–β2-syntrophin (HA-β2-syn ΔPH1) was coimmunoprecipitated with ARMS. (E) HA–β2-syn ΔPH1 did not induce ARMS clustering. Bar, 10 μm.