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. 2005 Jun 6;169(5):813–824. doi: 10.1083/jcb.200412008

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — Tyrosine phosphorylation of EphA4 in differentiated C2C12 cells was impaired after the blockade of ARMS and α-syntrophin expression by siRNA. (A) Differentiated C2C12 muscle cells were transfected with siRNA against ARMS and were treated with 5 μg/ml ephrin-A1-Fc chimera for 10 min. Decreased tyrosine phosphorylation of EphA4 was observed in the cells transfected with ARMS siRNA compared with the control oligo. (B) α-Syntrophin siRNA was transfected at the same condition as the ARMS siRNA. Reduced tyrosine phosphorylation of EphA4 was also observed. Un, untransfected cells that were not treated with ephrin-A1-Fc. For quantification data, the y axis represents the relative level of EphA4 tyrosine phosphorylation. Tyrosine phosphorylation in cells transfected with control oligos was normalized to 100%. n = 3; *, P < 0.005. Error bars represent the SEM.