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. 2005 Jun 20;169(6):929–939. doi: 10.1083/jcb.200412114

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Copyright © 2005, The Rockefeller University Press

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Figure 7. — The regulation of CLASP affinity for MTs does not require the COOH-terminal GSK3β motif. (A) Localization of selected EGFP-tagged CLASP2 constructs in the presence of 20 mM lithium chloride to inhibit GSK3β. Lithium chloride still induces ectopic lattice binding of EGFP-CLASP2(340–956), which lacks the COOH-terminal GSK3β motif. (B) Protein sequence of the COOH-terminal GSK3β motif. (C) EGFP-CLASP2(340–1084) constructs, which have either the two most conserved or all five potentially GSK3β-phosphorylated residues mutated to alanine, still track MT plus ends in the cell body and bind MT lattices in the lamella. Bar, 10 μm.