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. 2005 Jan 3;168(1):35–40. doi: 10.1083/jcb.200410115

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — MITF inhibits cell proliferation. (A) Western blot demonstrating MITF, p16^Ink4a, total Rb, Rb-phospho-Ser780, and tubulin protein expression in 10T1/2 mouse fibroblasts stably expressing ectopic MITF, MITF-DB (DNA-binding mutant), or empty control vector. Arrows indicate hyperphosphorylated (top band) and hypophosphorylated (bottom band) forms of Rb. (B) Growth curves of 10T1/2 cells stably expressing MITF or empty control vector. Panels show morphology of 10T1/2 cells expressing control empty vector (left) and MITF (right). (C) BrdU incorporation assays in 10T1/2 cells expressing ectopic MITF , MITF-DB, or empty control vector.