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. 2005 May 23;169(4):591–601. doi: 10.1083/jcb.200412139

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — Type I collagen expression and synthesis in FIAT transgenic mice. Femoral sections from wild-type (A) or FIAT transgenic (B) littermates were stained with the van Gieson dye to examine type I collagen expression. Bar, 500 μM. (C) Calvarial Col1A1 mRNA levels were quantified by real-time PCR. (D) Collagen protein content in whole tibias from 3-mo-old mice was estimated using hydroxyproline quantification. (E) Type I collagen synthesis analysis. The histogram shows expression of [³H]proline–labeled α1 and α2 chains of type I collagen relative to β-actin expression (n = 9 independent primary osteoblast cultures from different litters for each bar). NEAA, nonessential amino acids; Wt, wild-type; Tg, transgenics.