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. 2005 May 23;169(4):555–560. doi: 10.1083/jcb.200412024

Figure 4.

Figure 4.

Activation of caspase-12 and induction of CHOP in developing muscle tissue. (A) Caspase-12 was induced at the onset of muscle formation at E13.5 in embryo back muscle tissue. (B) Back muscle at E13.5 was specifically stained with antibody to active caspase-12. (C) Higher magnification of images in A and B. The muscle tissue at E13.5 was stained with antibody to caspase-12. Also shown is double-labeling of cells with anti-active caspase-12 antibody (brown) and antimyosin antibody (purple). (D and E) CHOP induction in back muscle tissues at E13.5. Arrows indicate nuclear accumulation of CHOP, whereas arrowheads point to cells with cytoplasmic CHOP. (F) Activation of caspase-12 in the presence of CHOP induction. Anti-p10N antibody, purple; CHOP, brown. Bars: (A, B, and D) 100 μm; (C, E, and F) 10 μm.