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. 2005 May 23;169(4):657–667. doi: 10.1083/jcb.200411034

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — Suggested model for the sensitization of EGF-induced Ca² ⁺ release and exocytosis by BK. The functionally silent EGF-induced Ca²⁺ signaling is acquired in response to BK stimulation via regulation of at least two components in the EGF signaling system, i.e., EGFR and IP₃R1. First, BK triggers Src-dependent phosphorylation of EGFR, which results in enhanced recruitment and activation of PLCγ1, thereby allowing for generation of IP₃. Second, BK induces PKA-dependent phosphorylation of IP₃R1, increasing its responsiveness to IP₃. IP₃ generated by PLC activation becomes capable of triggering Ca²⁺ release, which leads to neurotransmitter release.