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. 2005 Feb 14;168(4):607–618. doi: 10.1083/jcb.200406126

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — BoNT/C induces apoptosis in CGCs. (A) Time course of syntaxin and SNAP-25 cleavage analyzed by Western blot in CGC lysates. Cells were exposed to 20ng/ml BoNT/C for the time indicated. Concentration–response (B) and time course (C) of BoNT/C-induced cell death. In B, cell death was evaluated 30 h after treatment with the toxin, whereas in C, cells were exposed to 20 ng/ml BoNT/C in the absence or the presence of cycloheximide (CHX; 2 μM). Apoptosis is expressed as a percentage of condensed nuclei in cultures stained by H-33342 (D). Shown are HMM DNA fragmentation (E) and DNA laddering (F) in cultures exposed to 20 ng/ml BoNT/C for the indicated times. Data are means ± SD for triplicate determinations. Bar, 30 μm.