Table I. Effect of NE candidate proteins on GFPWT-torsinA.
| Candidate protein | Change in GFPWT-torsinA distribution |
|---|---|
| Emerin | None |
| gp210 | None |
| LAP1 | Increased NE labeling |
| LAP2β | None |
| Lamin B receptor | Puncta in ER/NE |
| LUMA | Puncta in ER/NE |
| MAN1 | None |
| Nesprin-1 | None |
| Nurim | None |
| NET3 | None |
| NET4 | None |
| NET26 | None |
| NET31 | None |
| NET39 | None |
| NET51 | None |
| Sun1 (Unc84A homologue) | None |
| Sun2 (Unc84B homologue) | Puncta in ER/NE |
| UNCL (Unc50 homologue) | None |
BHKGFPWT cells were transfected with NE resident proteins and transfected cells were identified by colabeling with antibodies against reporter proteins (see Fig. 2 A). The nuclear envelope transmembrane proteins (NET) are described by Schirmer et al. (2003) and UNCL by Fitzgerald et al. (2000). See Burke and Stewart (2002) for descriptions of other candidate proteins.