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. 2005 Feb 28;168(5):747–759. doi: 10.1083/jcb.200412003

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Copyright © 2005, The Rockefeller University Press

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Figure 10. — Model for the COG complex function in membrane trafficking. Cis-Golgi localized COG complex acts a tether for retrograde COPI-coated CCD vesicles that originate from the trans-Golgi/endosomal compartment(s). The COG3 KD abolishes vesicle tethering to the cis-Golgi. As a result multiple nontethered vesicles are transiently accumulated in cell cytoplasm and the membrane-depleted Golgi ribbon is fragmented into multiple Golgi mini-stacks.