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. 2005 May 9;169(3):405–413. doi: 10.1083/jcb.200411013

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Copyright © 2005, The Rockefeller University Press

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Figure 2. — Mnt–Max and Myc–Max complex switching on shared target genes. (a) Western blot showing c-Myc expression in wild-type (Mnt^+/+) and Mnt null (Mnt^−/−) MEFs at 0, 4, and 24 h after serum stimulation of quiescent cells. (b) ChIP analysis, performed in parallel with the Western blot shown in panel a, examining Mnt, c-Myc, and Max binding to specific E-box–containing regions in the Cdk4, Cyclin D2, ODC, Nucleolin, Telomerase (Tert) E2F2, CAD, and Cyclin E1 genes at 0, 4, and 24 h after serum stimulation. (c) Chromatin reimmunoprecipitation (ReIP) assays showing the presence of Sin3A and HDAC1 at several Mnt-Myc target genes. Pre, preimmune serum; Total, total input.