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. 2004 Feb 16;164(4):547–556. doi: 10.1083/jcb.200310046

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Sequence comparisons of human Npc1 and yeast Ncr1p. (A) Conserved domains in NPC1 and Ncr1p. In addition to the NPC domain that distinguishes the NPC1 gene family, Ncr1p retains a putative sterol-sensing domain (SSD) and several regions of similarity to the morphogen receptor, Patched (Patched homology domain, PHD). (B) The putative SSD of NPC1, Ncr1p, and SCAP. Residues 599–789 of human NPC1, 538–721 of yeast Ncr1p, and 264–444 of human SCAP are aligned. Sequence identity is indicated by the vertical bar and similarity by colons and periods. Across this region the NPC1 and Ncr1p sequences are 43% identical. The NCR1Y ₅₇₁C, NCR1Y ₇₁₈D, and NCR1Y ₇₁₈N variants are indicated.

Figure 1. — Sequence comparisons of human Npc1 and yeast Ncr1p. (A) Conserved domains in NPC1 and Ncr1p. In addition to the NPC domain that distinguishes the NPC1 gene family, Ncr1p retains a putative sterol-sensing domain (SSD) and several regions of similarity to the morphogen receptor, Patched (Patched homology domain, PHD). (B) The putative SSD of NPC1, Ncr1p, and SCAP. Residues 599–789 of human NPC1, 538–721 of yeast Ncr1p, and 264–444 of human SCAP are aligned. Sequence identity is indicated by the vertical bar and similarity by colons and periods. Across this region the NPC1 and Ncr1p sequences are 43% identical. The NCR1Y ₅₇₁C, NCR1Y ₇₁₈D, and NCR1Y ₇₁₈N variants are indicated.