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. 2004 Sep 27;166(7):949–955. doi: 10.1083/jcb.200312112

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — During mitosis RanGDP is converted into RanGTP in the proximity of the chromosomes by the nucleotide exchange factor RCC1. In a first step, RanGTP binds to importin β releasing it from importin α. The affinity of importin α for NLS sequences is reduced and a complex of importin α CAS and RanGTP forms releasing TPX2. CAS functions to reexport importin α to the cytoplasm. TPX2 triggers microtubule nucleation and binds to the mitotic kinase Aurora A activating it.