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. 2004 Sep 27;166(7):949–955. doi: 10.1083/jcb.200312112

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — Factors proposed to be regulated by RanGTP during mitosis and their role in spindle assembly. (A) Nucleation: in the initial phases chromosomes generate an environment enriched in RanGTP. TPX2 is released from the importins and triggers microtubule nucleation. (B) Organization: microtubules assembled around the chromosomes coalesce and start to organize. Two proteins were suggested to be regulated by RanGTP and to participate in these events: Eg5 and Kid. (C) Pole formation: microtubule minus ends focus into spindle poles. This process involves two proteins regulated by RanGTP: NuMA and XCTK2. TPX2 may also play a role in this process.