Table I.
Adaptive regrowth in yeast with different life span
| Strain | Adaptive regrowth
|
Mean Life Span |
||
|---|---|---|---|---|
| Yes | No | Percentage of regrowth |
||
| DBY746 (WT) | 42 | 46 | 48 | 6.2 |
| sod1Δ | 17 | 2 | 89c | 1 |
| sod1Δ ctt1Δ | 3 | 1 | 75 | 1 |
| ctt1Δ | 1 | 1 | 50 | 6.2 |
| sod1Δ Bcl-2 | 4 | 6 | 40 | 6.2 |
| SOD1ox SOD2ox | 0 | 9 | 0c | 7.8 |
| SOD1ox CTT1ox | 0 | 13 | 0c | 7.5 |
| SOD1ox | 6 | 13 | 31.5c | 7.2 |
| SOD2ox | 0 | 6 | 0c | 6.65 |
| CTT1ox | 3 | 7 | 30c | 6.2 |
| Bcl-2ox | 0 | 9 | 0c | 7 |
| ras2Δ | 0 | 15 | 0c | 15 |
| sch9Δ | 0 | 14 | 0c | 19 |
| yap1Δ | 1 | 10 | 10c | 6 |
| skn7Δ | 2 | 10 | 20c | 6 |
| SP1 (WT) | 3 | 1 | 75 | 7.8 |
| SOD1ox | 1 | 3 | 25 | 9 |
| Summary | ||||
| WT | 45 | 47 | 49c | 7 |
| Long-liveda | 6 | 82 | 6.8c | 9.9 |
| Short-livedb | 20 | 3 | 87c | 1 |
a
Superoxide resistant: SOD1ox SOD2ox, SOD1ox CTT1ox, SOD1ox, SOD2ox, Bcl-2ox, ras2Δ, and sch9Δ.
b
Superoxide sensitive: sod1Δ and sod1Δ ctt1Δ.
c
Significantly different versus wild type (WT). When four or less samples were available, the corresponding strains were excluded from statistical analysis. Chi square test (χ2 = 64, df = 10, P < 0.05) followed by Scheffé's post-test for multiple comparisons (P < 0.05).