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. 2004 Mar 29;164(7):1077–1087. doi: 10.1083/jcb.200401115

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Transitional AChR aggregate morphologies in vivo and in vitro. (A–D) AChR-rich postsynaptic specializations at the NMJ are initially plaque-shaped (A), perforated (B), C-shaped (C), and branched (D) structures become successively more prevalent as development proceeds. Postnatal ages (P) are indicated in each panel. (E–H) AChR aggregates formed on laminin-coated substrates in the absence of innervation also display plaque-shaped, perforated, C-shaped, and branched shapes. PF, days after initiating fusion. (I) The diameter of myotubes bearing aggregates of the four morphological types shown in A–H. n = 32–147 clusters per point, from a 5-d postfusion culture. Diameter was measured at the cluster. The schematic applies to I and J. (J) The prevalence of morphologies in vitro as a function of days PF. n = 205–232 clusters per time point. Bar, 20 μm for all panels.