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. 1998 Sep 29;95(20):11804–11809. doi: 10.1073/pnas.95.20.11804

Figure 1.

Figure 1

EM views of NAR show it to be a dimer with single, bivalent V domains. Small, flexible knobs are present at one end of NAR (A, B, E, and F), and a torsion of the last quarter of the molecule is seen at the other end (B). The small knobs are approximately one-quarter the size of the control human IgG Fab regions (D), i.e., the size of a single Ig domain. An mAb specific for the NAR C terminus orients NAR and indicates that the small knobs are the V regions (E and F). mAb were bound either by one Fab arm (E) or both Fab arms (F). Complexes are oriented so that the mAbs are at the bottom of the images. (Bar = 20 nm.) (G) Model of NAR showing dimensions and hypothetical domain orientations and flexibility patterns.