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. 2004 May 10;165(3):335–346. doi: 10.1083/jcb.200403061

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Loss of PS1 γ-secretase activity does not result in the formation of enlarged perinuclear organelles. PS1 +/? neurons were treated for 7 d with the γ-secretase inhibitors L-685,458 (1 μM), DFK-167 (50 μM), III-31C (5 μM), 2-Napthyl-VF-CHO (20 μM), or LiCl (5 mM), and analyzed by light microscopy for Lamp-2 and synuclein immunoreactivity. None of these compounds increased the percentage of neurons containing Lamp-2–positive enlarged perinuclear organelles, nor did they induce the localization of synuclein proteins to this site. 100 nM staurosporine treatment for 48 h was included as a positive control. Asterisks indicate that the results are statistically significant, P < 0.005. Error bars represent SD.