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Schematic for the antephase checkpoint. Several different insults are able to block cells in antephase, some or all of which may act through the p38 stress kinases. The Chfr protein appears to be required to activate the checkpoint in response to microtubule poisons but not to UV or H2O2 and probably signals through ubiquitin conjugation, perhaps through the TAK1 kinase. Note that this is only a tentative model.
