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. 2004 Aug 16;166(4):517–526. doi: 10.1083/jcb.200405167

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — Inhibiting p38 does not override the ATM/DNA damage checkpoint. (A) When the nucleus of early prophase PtK₁ cells is irradiated with 50 pulses of laser light the chromosomes decondense and the cell returns to an interphase morphology. This response is not prevented by inhibiting p38 with SB203580 (A), but it is prevented when the ATM kinase is inhibited with caffeine (B). The cell in B was fixed after NEB and processed for the detection of both DNA (Hoechst) and DSBs (γ–H2Ax). Bars, 10 μm.