Table 2.

Distribution of BCL-6 mutations in neoplastic diseases

Histology	Mutated/tested	%	Normal counterpart
B cell malignancies
B-ALL	0/19	0	Pre-B cell
MCL	1/19	5	Pre-GC B cell
B-CLL	5/33	15	CD5+ B cell
FL	10/27	37	GC B cell
BL*	11/30	37	GC B cell
DLCL	48/81	59	GC B cell
MM	19/58	33	Post-GC B cell
Non-B cell malignancies
T cell neoplasms†	2/35	6	T cell
Myeloid leukemias‡	0/52	0	Stem cell/myeloid cell
Solid tumors§	0/123	0	Various

^*Including 17 cases and 13 cell lines. 

^†T cell acute lymphoblastic leukemia (six cases), T-cell chronic lymphocytic leukemia (14 cases), peripheral T cell lymphoma (15 cases). 

^‡Acute myeloid leukemia (44 cases) and chronic myeloid leukemia (eight cases). 

^§Breast, prostate, stomach, colon, liver, and kidney carcinomas and glioblastomas (data from ref. 9). 

B-ALL, B-cell acute lymphoblastic leukemia; MCL, mantle cell lymphoma; B-CLL, B-cell chronic lymphocytic leukemia; MM, multiple myeloma.