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. 2004 Jul 19;166(2):261–272. doi: 10.1083/jcb.200401034

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Figure 3. — Effects of the mAChR signaling modifiers on migration of human KCs. The migration assays of intact or siRNA-M₃– or siRNA-M₄–transfected KCs were performed in AGKOS plates. The cells were exposed to 1 μM thapsigargin (TG), 10 μM LY-83,583 (LY), 1 mM SQ 22536 (SQ), 50 μM Sp-8-Br-cAMPS (Sp), 5 μM 8-pCPT-cGMP (8p),1 μM Rp-8-pCPT-cGMPS (Rp), 25 nM KT5720 (KT), 10 μg/ml C3 exoenzyme (C3), 5 μM Y-27632 (Y), or 10 nM MT3 dissolved in KGM. Some cells were pretreated for 30 min with thapsigargin, Rp-8-pCPT-cGMPS, or KT5720 before exposing them to a second test agent versus no additional (NA) treatment. The results are expressed as means ± SD of nontreated control, taken as 100%. *, significant (P < 0.05) differences from control. Significant differences between specific experimental conditions are indicated in the graph with square brackets with arrows.