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. 2004 Jul 19;166(2):205–211. doi: 10.1083/jcb.200404150

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Comparison of S. pombe PTEN proteins. (A) Alignment of human and S. pombe proteins (DNA Star program, J. Hein method). Open box, 4–amino acid insertion; shaded box, residues forming H-bonds with PI(3,4,5)P₃; black box, positive charges at active site. (B) Signature sequences for seven species. S. pombe protein is similar to PTEN in higher organisms. (C) Human and S. pombe PTEN phosphatases have similar specificities for PI substrates. Specific activities are reported as moles of phosphate released per mole of GST-PTEN per minute. Error bars are ± SEM.