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. 2004 Jan 19;164(2):313–323. doi: 10.1083/jcb.200309134

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — Invertebrate and vertebrate claudins form a highly divergent protein family. The phylogenetic tree resulting from a bootstrap analysis of aligned claudin family member sequences (Fig. S1, available at http://www.jcb.org/cgi/content/full/jcb.200309134/DC1; see Materials and methods). Numbers indicate the frequency with which particular nodes occurred among individual trees generated from 1,000 random samplings of the aligned sequences. Unlabeled nodes occurred in <51% of individual trees. Dog TM4SF10 is also known as BCMP-1 (Christophe-Hobertus et al., 2001). fly, D. melanogaster; Dre, zebra fish; ce, C. elegans; Hro, Halocynthia roretzi.