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. 2004 May 24;165(4):505–515. doi: 10.1083/jcb.200307164

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Model illustrating the dual mechanism by which the A forms of AChE are accumulated at synaptic sites. The two types of interactions between (a) the COOH terminus of ColQ and MuSK, and (b) the two HBS (gray boxes) in the collagen domain of ColQ and perlecan are shown. The interaction of perlecan and dystroglycan (αDG and βDG) is also represented. This model accounts for the accumulation of AChE in the synaptic basal lamina enriched in perlecandystroglycan and for its precise localization at postsynaptic sites via MuSK.